Terminology Service for NFDI4Health

Pro-Neuregulin-2, Membrane-Bound Isoform

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Pro-neuregulin-2, membrane-bound isoform (850 aa, ~92 kDa) is encoded by the human NRG2 gene. This protein plays a role in receptor signaling. [ ]

Term info

Label

Pro-Neuregulin-2, Membrane-Bound Isoform

Synonyms
  • Pro-NRG2
  • Pro-Neuregulin-2
  • Pro-Neuregulin-2, Membrane-Bound Isoform
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The active form of the growth factor, neuregulin-2, is produced by two proteolytic cleavage events that remove the 111 N-terminal amino acid propeptide and 446 amino acids from the C-terminus of pro-neuregulin-2, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt)

Display Name

Pro-Neuregulin-2, Membrane-Bound Isoform

OMIM Number

603818

Preferred Name

Pro-Neuregulin-2, Membrane-Bound Isoform

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

O14511

UMLS CUI

C3888284

code

C118416