Terminology Service for NFDI4Health
Pro-Neuregulin-3, Membrane-Bound Isoform
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http://purl.obolibrary.org/obo/NCIT_C118418
Pro-neuregulin-3, membrane-bound isoform (720 aa, ~78 kDa) is encoded by the human NRG3 gene. This protein plays a role in signaling. [ ]
Term info
Label
Pro-Neuregulin-3, Membrane-Bound Isoform
Synonyms
- Pro-NRG3
- Pro-Neuregulin-3
- Pro-Neuregulin-3, Membrane-Bound Isoform
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
The active form of the growth factor, neuregulin-3, is produced when proteolytic cleavage removes 361 amino acids from the C-terminus of pro-neuregulin-3, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt)
Display Name
Pro-Neuregulin-3, Membrane-Bound Isoform
OMIM Number
605533
Preferred Name
Pro-Neuregulin-3, Membrane-Bound Isoform
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
P56975
UMLS CUI
C3888285
code
C118418
Term relations
Subclass of:
- NRG3 Gene Product
- Gene_Product_Plays_Role_In_Biological_Process some Cell Proliferation
- Gene_Product_Has_Structural_Domain_Or_Motif some Cytoplasmic Domain
- Gene_Product_Has_Structural_Domain_Or_Motif some EGF-Like Domain
- Gene_Product_Encoded_By_Gene some NRG3 Gene
- Gene_Product_Plays_Role_In_Biological_Process some Intercellular Communication Process
- Gene_Product_Has_Associated_Anatomy some Plasma Membrane
- Gene_Product_Has_Organism_Source some Human
- Gene_Product_Plays_Role_In_Biological_Process some Cell Differentiation Process
- Gene_Product_Has_Structural_Domain_Or_Motif some Transmembrane Domain