Terminology Service for NFDI4Health

Aggresome

Go to external page http://purl.obolibrary.org/obo/NCIT_C118897


A ubiquitin-rich cytoplasmic inclusion encased in vimentin found near the microtubule organizing center. It is formed in response to cellular stresses that cause the production of misfolded proteins at levels that exceed the degradative capacity of the proteasome. This inclusion body is comprised of aggregated misfolded or denatured proteins that have been transported along microtubules to the pericentriolar space where they become encased in vimentin. [ ]

Term info

Label

Aggresome

Synonyms
  • Aggresome
Subsets

NCIT_C116977, NCIT_C142799

Display Name

Aggresome

Preferred Name

Aggresome

Semantic Type

Cell Component

UMLS CUI

C1167059

code

C118897