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DNAJB1/PRKACA Fusion Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C122559

A fusion protein that is encoded by the DNAJB1/PRKACA fusion gene. This protein contains the N-terminus of DnaJ homolog subfamily B member 1 protein fused to almost the entire cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) protein. The chimeric protein lacks the PKA C-alpha domains that interact with PKA regulatory subunits. [ ]

Term info

Label

DNAJB1/PRKACA Fusion Protein

Synonyms
  • DNAJB1-PRKACA Fusion Protein
  • DNAJB1/PRKACA Fusion Protein
  • DnaJ Homolog Subfamily B Member 1-cAMP-Dependent Protein Kinase Catalytic Subunit Alpha Fusion Protein
  • DnaJ Homolog Subfamily B Member 1/cAMP-Dependent Protein Kinase Catalytic Subunit Alpha Fusion Protein
  • HSP40-PKA C-alpha Fusion Protein
  • HSP40/PKA C-alpha Fusion Protein
DesignNote

The DNAJB1/PRKACA fusion protein is expressed in a pattern that differs from that of the wild-type PKA C-alpha protein but it demonstrates PKA C-alpha kinase activity. (Science. 2014; 343: 1010-1014.)

Preferred Name

DNAJB1/PRKACA Fusion Protein

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C38409, http://purl.obolibrary.org/obo/NCIT_C122560

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C4055165

code

C122559