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Megakaryocyte-Potentiating Factor

Go to external page http://purl.obolibrary.org/obo/NCIT_C128317

Megakaryocyte-potentiating factor (250 aa, ~27 kDa) is encoded by the human MSLN gene. This protein plays a role in megakaryocyte colony formation. [ ]

Term info

Label

Megakaryocyte-Potentiating Factor

Synonyms
  • MPF
  • Megakaryocyte Potentiating Factor
  • Megakaryocyte-Potentiating Factor
  • OV569 Antigen
  • SMR
  • SMRP
  • Soluble MPF Mesothelin Related Protein
  • Soluble MPF/Mesothelin Related Protein
  • Soluble MPF/Mesothelin-Related Protein
  • Soluble Mesothelin Related Protein
  • Soluble Mesothelin/MPF-Related Protein
  • Soluble Mpf/Mesothelin-Related Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink)

Display Name

Megakaryocyte-Potentiating Factor

OMIM Number

601051

Preferred Name

Megakaryocyte-Potentiating Factor

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

Q13421

UMLS CUI

C1651474

code

C128317