Terminology Service for NFDI4Health
Receptor Tyrosine-Protein Kinase erbB-2 Carboxyl Terminal Fragment
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http://purl.obolibrary.org/obo/NCIT_C129898
Receptor tyrosine-protein kinase erbB-2 carboxyl terminal fragment is encoded by the human ERBB2 gene. This protein may be involved in tyrosine kinase activity and may be associated with increased cancer severity. [ ]
Term info
Label
Receptor Tyrosine-Protein Kinase erbB-2 Carboxyl Terminal Fragment
Synonyms
- ERBB2 C-Terminal Fragment
- ERBB2 CTF
- ERBB2 Carboxyl Terminal Fragment
- ERBB2-p95
- HER2 C-Terminal Fragment
- HER2 CTF
- HER2-p95
- HER2/neu CTF
- HER2/neu-p95
- Receptor Tyrosine-Protein Kinase erbB-2 C-Terminal Fragment
- Receptor Tyrosine-Protein Kinase erbB-2 CTF
- Receptor Tyrosine-Protein Kinase erbB-2 Carboxyl Terminal Fragment
- p95 HER2
- p95HER2
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
Receptor tyrosine-protein kinase erbB-2 carboxyl terminal fragments (ERBB2 CTF) arise through at least two different mechanisms: proteolytic shedding of the full-length receptor tyrosine-protein kinase erbB-2 extracellular domain and translation of ERBB2 mRNA from internal initiation codons. ERBB2 CTFs resulting from either proteolytic shedding of the extracellular domain or alternative initiation of ERBB2 mRNA from methionine codon 611 contain the transmembrane domain and the intracellular domain (ICD) of the ERBB2 protein and maintain tyrosine kinase activity. Alternative initiation of ERBB2 mRNA from methionine codon 687 results in an ERBB2 CTF that only includes the ICD, which is soluble and localized to the cytoplasm and nucleus; this form does not appear to have tyrosine kinase activity.
Display Name
Receptor Tyrosine-Protein Kinase erbB-2 Carboxyl Terminal Fragment
NCI META CUI
CL512925
OMIM Number
164870
Preferred Name
Receptor Tyrosine-Protein Kinase erbB-2 Carboxyl Terminal Fragment
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
P04626
code
C129898