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Dolastatin 10

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A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04) [ ]

Term info

Label

Dolastatin 10

Synonyms
  • B720389K560
  • Dolastatin 10
  • Dolastatin-10
  • L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]
  • dolastatin 10
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of cancer. It binds to a protein that cells need to divide and it may kill cancer cells. Dolastatin 10 comes from a marine organism. It is a type of mitotic inhibitor.

CAS Registry

110417-88-4

Display Name

Dolastatin 10

Legacy Concept Name

Dolastatin_10

NSC Code

376128

Preferred Name

Dolastatin 10

Semantic Type

Pharmacologic Substance, Amino Acid, Peptide, or Protein

UMLS CUI

C0082338

code

C1300