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BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.895G>C Mutation

Go to external page http://purl.obolibrary.org/obo/NCIT_C130213

A fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of a mutated form of the ABL1 gene. In this fusion gene there is a point mutation where guanine has been substituted with cytosine at nucleotide position 895 of the ABL1 gene. This mutation is associated with imatinib- and dasatinib-resistant leukemias. [ ]

Term info

Label

BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.895G>C Mutation

Synonyms
  • BCR/ABL Fusion Gene with NM_005157.4:c.895G>C
  • BCR/ABL Fusion Gene with NM_005157.5:c.895G>C
  • BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.895G>C Mutation
  • BCR/ABL1 Fusion Gene with ABL1 NM_005157.5:c.895G>C
  • BCR/ABL1 Fusion Gene with NM_005157.4:c.895G>C
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The position of the point mutation is denoted by its location in the ABL1 cDNA sequence (NCBI Reference Sequence: NM_005157.4) and not its location in the fusion gene cDNA.

Display Name

BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.895G>C Mutation

NCI META CUI

CL513808

Preferred Name

BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.895G>C Mutation

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C17346, http://purl.obolibrary.org/obo/NCIT_C18455

Semantic Type

Gene or Genome

code

C130213