Terminology Service for NFDI4Health
E1 Ubiquitin-Activating Enzyme
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http://purl.obolibrary.org/obo/NCIT_C133714
A ligase that catalyzes the first step in the ubiquitination reaction via the ligation of the C-terminal lysine of ubiquitin to the E1 enzyme in an ATP-dependent reaction. [ ]
Term info
Label
E1 Ubiquitin-Activating Enzyme
Synonyms
- E1 Ubiquitin-Activating Enzyme
- EC 6.2.1.45
- EC 6.3.2.19, Formerly
- Ubiquitin-Activating Enzyme
DesignNote
The IUBMB has recategorized E2 ubiquitin-conjugating enzymes and E3 ubiquitin-protein ligases as transferases (EC 2), and E1 enzymes have had their designation changed from EC 6.3.2.19 to EC 6.2.1.45. Thus, E1, E2 and E3 enzymes may be considered part of a ubiquitin ligase complex, but only E1 enzymes are categorized as ligases (EC 6).
Preferred Name
E1 Ubiquitin-Activating Enzyme
Semantic Type
Amino Acid, Peptide, or Protein, Enzyme
UMLS CUI
C0163974
code
C133714