Terminology Service for NFDI4Health
Coiled-Coil Domain
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http://purl.obolibrary.org/obo/NCIT_C13967
A domain that stabilizes alpha helices in proteins through a very efficient burial of hydrophobic side chains so that polar water molecules do not access them. As a result, the helices are quite stable. In fact, many structural proteins (keratins, tropomyosin, laminin) that have to bear considerable stress have a coiled-coil domain. Two basic essential features are common: (1) the overall secondary structure is alpha helical, (2) the hydrophobic residues are arranged on one side of the helices. The typical positioning of the hydrophobic residues in the coiled-coil domain can be often recognized from primary structure of the protein. The helices can be parallel or antiparallel. The former is common when the helices belong to different polypeptides and the latter prevails in coiled coils made up from a single polypeptide chain. The number of helices in the coil varies usually between 2 and 4. [ ]
Term info
Label
Coiled-Coil Domain
Synonyms
- 4-3 Hydrophobic Repeat
- Coiled Coil
- Coiled Coil Domain
- Coiled-Coil
- Coiled-Coil Domain
- Left-Handed Twist
Legacy Concept Name
Coiled-Coil_Domain
Preferred Name
Coiled-Coil Domain
Semantic Type
Amino Acid Sequence
UMLS CUI
C1516692
code
C13967
Term relations
Related from:
Gene_Product_Has_Structural_Domain_Or_Motif
- RanBP2-Like and GRIP Domain-Containing Protein 3
- Coiled-Coil Domain-Containing Protein 170
- EMILIN-1
- Glomulin
- Transforming Acidic Coiled-Coil-Containing Protein 2
- Plasmalemma Vesicle-Associated Protein
- Golgi Membrane Protein 1
- Small Kinetochore-Associated Protein
- Pentraxin-Related Protein PTX3
- RUN Domain-Containing Protein 1
- Myb/SANT-Like DNA-Binding Domain-Containing Protein 3
- Paralemmin-2
- A-Kinase Anchor Protein 2
- WD Repeat and Coiled-Coil-Containing Protein
- Cytospin-B
- Shootin-1
- Zinc Finger CCHC Domain-Containing Protein 8
- Centrosomal Protein of 89 kDa
- Epithelial-Stromal Interaction Protein 1
- Rho Guanine Nucleotide Exchange Factor 10
- Rho Guanine Nucleotide Exchange Factor 10-Like Protein
- Melanophilin
- Nesprin-2
- Putative Coiled-Coil Domain-Containing Protein 26
- Basic Helix-Loop-Helix Domain-Containing Protein USF3
- Coiled-Coil Domain-Containing Protein 6
- Transmembrane and Coiled-Coil Domains Protein 1
- Rho GTPase-Activating Protein 22
- Protein ZNF365
- Centrosome-Associated Protein 350
- Fibroleukin
- Protein MRVI1
- Dynein Heavy Chain 9, Axonemal
- Cancer-Associated Gene 1 Protein
- Ankyrin Repeat Domain-Containing Protein 24
- Nesprin-1
- Pleckstrin Homology-Like Domain Family B Member 3
- Serine-Rich Coiled-Coil Domain-Containing Protein 1
- Ankyrin Repeat Domain-Containing Protein 26
- Geminin Coiled-Coil Domain-Containing Protein 1
- Protein PRRC1
- FKBP-Associated Protein 48 kDa
- Transforming Acidic Coiled-Coil-Containing Protein 1