Terminology Service for NFDI4Health
Proline-Rich Domain
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http://purl.obolibrary.org/obo/NCIT_C14106
Proline-Rich Domains may be involved in heterotypic protein-protein interactions in signal transduction or other pathways. Found in signaling and structural proteins, WW domains are composed of approximately 40 amino acids folded as a stable, triple stranded beta-sheet that recognize proline-rich sequences. Some WW domains show a remarkable similarity to SH3 domains, which also appear to recognize some proline-rich sequences. Ena/VASP (Drosophila Enabled/Vasodilator-Stimulated Phosphoprotein) Family members regulate actin filament assembly, often through association with binding partners that display a proline-rich FPPPP motif. Ena/VASP proteins interact with these partners via the highly conserved Ena/VASP homology 1 (EVH1) domain. (NCI) [ ]
Term info
Label
Proline-Rich Domain
Synonyms
- Pro-Rich
- Proline Rich Domain
- Proline Rich Region
- Proline-Rich Domain
- Proline-Rich Region
Legacy Concept Name
Proline-Rich_Domain
Preferred Name
Proline-Rich Domain
Semantic Type
Amino Acid Sequence
UMLS CUI
C1514490
code
C14106
Term relations
Related from:
Gene_Product_Has_Structural_Domain_Or_Motif
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- Cyclic Nucleotide-Binding Domain-Containing Protein 1
- Proline-Rich Protein PRCC
- Proline-Rich Transmembrane Protein 2
- NUT Family Member 2A
- NUT Family Member 2B
- Nuclear Pore Complex-Interacting Protein Family Member B8
- Shootin-1
- Survival Motor Neuron Protein
- Proline-Rich Nuclear Receptor Coactivator 1
- Ribonucleoprotein PTB-Binding 1
- Biorientation of Chromosomes in Cell Division Protein 1-Like 1
- Lysosomal-Associated Transmembrane Protein 5
- Epidermal Growth Factor Receptor Kinase Pathway Substrate 8-Like Protein 3
- Epidermal Growth Factor Receptor Kinase Pathway Substrate 8-Like Protein 1
- Histidine-Rich Glycoprotein
- Protein PRRC1
- Protein ALEX
- Uncharacterized Protein C11orf95