Human KDM4C wild-type allele is located in the vicinity of 9p24.1 and is approximately 455 kb in length. This allele, which encodes lysine-specific demethylase 4C protein, plays a role in the demethylation of histone H3. Chromosomal aberrations involving the gene and aberrant expression of this gene may be associated with esophageal squamous cell carcinoma and other neoplastic diseases. [ ]