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Nesprin-1

Go to external page http://purl.obolibrary.org/obo/NCIT_C150329

Nesprin-1 (8797 aa, ~1011 kDa) is encoded by the human SYNE1 gene. This protein plays a role in linking the nuclear lamina and the cytoskeleton. [ ]

Term info

Label

Nesprin-1

Synonyms
  • Enaptin
  • KASH Domain-Containing Protein 1
  • KASH1
  • Myne-1
  • Myocyte Nuclear Envelope Protein 1
  • Nesprin 1
  • Nesprin-1
  • Nuclear Envelope Spectrin Repeat Protein 1
  • SYNE1
  • Spectrin Repeat Containing Nuclear Envelope Protein 1
  • Spectrin Repeat-Containing Nuclear Envelope Protein 1
  • Synaptic Nuclear Envelope Protein 1
  • Syne-1
DesignNote

Nesprin-1 is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex that connects nuclear lamina proteins to the actin cytoskeleton. These links transmit mechanical forces across the nuclear envelope and regulate nuclear movement and positioning. (UniProt)

NCI META CUI

CL552093

OMIM Number

608441

Preferred Name

Nesprin-1

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

Q8NF91

code

C150329