Terminology Service for NFDI4Health

Gemcitabine-Releasing Intravesical System

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A controlled-release intravesical system consisting of a small flexible tube-like device with a solid core composed of gemcitabine, a broad-spectrum antimetabolite and deoxycytidine analogue, with antineoplastic activity. Upon placement of the gemcitabine-releasing intravesical system (GemRIS) into the bladder, gemcitabine is gradually and continuously released from the system over an extended period of time before being removed from the bladder. Upon release, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA, resulting in premature termination of DNA replication and the induction of apoptosis of bladder tumor cells. In addition, dFdCDP inhibits ribonucleotide reductase (RNR) and reduces the deoxynucleotide pool available for DNA synthesis. [ ]

Term info

Label

Gemcitabine-Releasing Intravesical System

Synonyms
  • GemRIS
  • Gemcitabine-Releasing Intravesical System
  • TAR 200
  • TAR-200
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

Display Name

Gemcitabine-Releasing Intravesical System

NCI META CUI

CL552666

Preferred Name

Gemcitabine-Releasing Intravesical System

Semantic Type

Pharmacologic Substance, Nucleic Acid, Nucleoside, or Nucleotide

code

C150807