Terminology Service for NFDI4Health
JSON

CDK2/4/6/FLT3 Inhibitor FN-1501

Go to external page http://purl.obolibrary.org/obo/NCIT_C155956

A small molecule multi-kinase inhibitor of cyclin-dependent kinase (CDK) subtypes 2 (CDK2), 4 (CDK4), and 6 (CDK6) and FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1), with potential antineoplastic activity. Upon intravenous administration, CDK2/4/6/FLT3 inhibitor FN-1501 binds to and inhibits CDK2, CDK4, and CDK6, as well as FLT3. This may induce apoptosis and inhibit tumor cell proliferation in cancer cells that overexpress these kinases. CDKs are serine/threonine kinases that assist in cell cycle regulation and cellular proliferation. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in many cancer types. [ ]

Term info

Label

CDK2/4/6/FLT3 Inhibitor FN-1501

Synonyms
  • 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide
  • CDK/FLT3 Inhibitor FN-1501
  • CDK2/4/6/FLT3 Inhibitor FN-1501
  • FN 1501
  • FN-1501
  • FN1501
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

CAS Registry

1429515-59-2

Display Name

CDK2/4/6/FLT3 Inhibitor FN-1501

Has Target

http://purl.obolibrary.org/obo/NCIT_C17767, http://purl.obolibrary.org/obo/NCIT_C20492

NCI META CUI

CL562813

Preferred Name

CDK2/4/6/FLT3 Inhibitor FN-1501

Semantic Type

Pharmacologic Substance, Organic Chemical

code

C155956