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Safingol

Go to external page http://purl.obolibrary.org/obo/NCIT_C1568

A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. [ ]

Term info

Label

Safingol

Synonyms
  • (2S,3S)-2-Amino-1,3-Octadecanediol
  • Kynacyte
  • L-(-)-threo-Sphingnine
  • L-Threo-Dihydrosphingosine
  • L-threo-2-Amino-1,3-octadecanediol
  • L-threo-dihydrosphingosine
  • SAFINGOL
  • SPC-100270
  • Safingol
  • Sphinganine
  • safingol
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein kinase inhibitors.

CAS Registry

15639-50-6

Chemical Formula

C18H39NO2

Display Name

Safingol

FDA UNII Code

OWA98U788S

Has Salt Form

http://purl.obolibrary.org/obo/NCIT_C80327

Legacy Concept Name

Dihydrosphingosine

NSC Code

714503

Preferred Name

Safingol

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0281466

code

C1568