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Alvocidib Hydrochloride

Go to external page http://purl.obolibrary.org/obo/NCIT_C1571

A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. [ ]

Term info

Label

Alvocidib Hydrochloride

Synonyms
  • (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5, 7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-
  • ALVOCIDIB HYDROCHLORIDE
  • Alvocidib Hydrochloride
  • Flavopiridol Hydrochloride
  • HL-275
  • HMR 1275
  • L-86-8275
  • L-868275
  • MDL 107,826A
  • MDL-107826A
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of several types of cancer. It stops cells from dividing and may kill cancer cells. It is a type of cyclin-dependent kinase (CDK) inhibitor.

CAS Registry

131740-09-5

Chemical Formula

C21H20ClNO5.HCl

Display Name

Alvocidib Hydrochloride

FDA UNII Code

D48MS3A6N9

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C74940

Has Target

http://purl.obolibrary.org/obo/NCIT_C17767

Legacy Concept Name

Flavopiridol

NSC Code

649890

Preferred Name

Alvocidib Hydrochloride

Semantic Type

Pharmacologic Substance

UMLS CUI

C0281603

code

C1571