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Alitretinoin

Go to external page http://purl.obolibrary.org/obo/NCIT_C1574

An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. [ ]

Term info

Label

Alitretinoin

Synonyms
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid
  • 9-Cis-Retinoic Acid
  • 9-cRA
  • 9-cis Retinoic Acid
  • 9-cis retinoic acid
  • 9-cis-RA
  • 9-cis-Retinoic Acid
  • ALITRETINOIN
  • ALRT1057
  • Alitretinoin
  • LGD1057
  • Panretin
  • Panretyn
  • Panrexin
  • Retinoicacid-9-cis
Subsets

NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A drug being studied for cancer prevention. It belongs to the family of drugs called retinoids.

Accepted Therapeutic Use For

Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi sarcoma

CAS Registry

5300-03-8

CHEBI ID

CHEBI:50648

Chemical Formula

C20H28O2

FDA UNII Code

1UA8E65KDZ

Legacy Concept Name

Alitretinoin

NSC Code

659772

Preferred Name

Alitretinoin

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0281666

code

C1574