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BCR/ABL1 Fusion Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C16325

A fusion protein encoded by the BCR/ABL1 fusion gene. This protein is comprised of the N-terminus of the breakpoint cluster region protein fused to almost the entire tyrosine-protein kinase ABL1 protein. [ ]

Term info

Label

BCR/ABL1 Fusion Protein

Synonyms
  • BCR ABL Fusion Protein
  • BCR-ABL Oncoprotein
  • BCR-ABL Protein Tyrosine Kinase
  • BCR-ABL fusion protein
  • BCR-ABL1 Fusion Protein
  • BCR/ABL
  • BCR/ABL Chimeric Protein
  • BCR/ABL Fusion Protein
  • BCR/ABL Oncoprotein
  • BCR/ABL1 Fusion Protein
  • Breakpoint Cluster Region/Tyrosine-Protein Kinase ABL1 Fusion Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The BCR/ABL1 fusion protein is a constitutively activated tyrosine kinase and has a cytoplasmic localization, in contrast with the mostly nuclear localization of the tyrosine-protein kinase ABL1 protein. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)

Display Name

BCR/ABL1 Fusion Protein

Legacy Concept Name

BCR-ABL_Oncoprotein

Preferred Name

BCR/ABL1 Fusion Protein

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C17346, http://purl.obolibrary.org/obo/NCIT_C18455

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0004891

code

C16325