Terminology Service for NFDI4Health
DNA Polymerase Delta
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http://purl.obolibrary.org/obo/NCIT_C16511
A protein complex that has dual enzymatic activities in DNA synthesis. The enzyme complex both facilitates DNA synthesis by acting as a polymerase and exhibits exonuclease activity that degrades single stranded DNA in the 3' to 5' direction. It is a heterotetramer comprised of the DNA polymerase delta catalytic subunit and 3 DNA polymerase delta accessory subunits. [ ]
Term info
Label
DNA Polymerase Delta
Synonyms
- DNA Polymerase Delta
- DNA Polymerase Delta Complex
- Delta DNA Polymerase
DesignNote
DNA polymerase delta interaction with the proliferating cell nuclear antigen and the multisubunit replication factor C is essential for leading strand synthesis. (UniProt)
Legacy Concept Name
DNA_Polymerase_Delta
Preferred Name
DNA Polymerase Delta
Semantic Type
Amino Acid, Peptide, or Protein, Enzyme
UMLS CUI
C0012890
code
C16511
Term relations
Subclass of:
- Protein or Riboprotein Complex
- Gene_Product_Plays_Role_In_Biological_Process some DNA Replication Proofreading
- Gene_Product_Plays_Role_In_Biological_Process some DNA Synthesis
- Gene_Product_Plays_Role_In_Biological_Process some Excision Repair
- Gene_Product_Has_Biochemical_Function some DNA-directed DNA Polymerase