Terminology Service for NFDI4Health

Gamma-Glutamylcysteine Synthetase

Go to external page http://purl.obolibrary.org/obo/NCIT_C16602


Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink) [ ]

Term info

Label

Gamma-Glutamylcysteine Synthetase

Synonyms
  • EC 6.3.2.2
  • Gamma-Glutamylcysteine Synthetase
  • Gamma-Glutamylcysteinyl Synthetase
  • Glutamate-Cysteine Ligase
Legacy Concept Name

Gamma-Glutamylcysteine_Synthetase

Preferred Name

Gamma-Glutamylcysteine Synthetase

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

UMLS CUI

C0017037

code

C16602