Terminology Service for NFDI4Health
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Heat Shock Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C16672

A family of highly-conserved proteins that are synthesized in response to hyperthermia (heat shock), hypoxia, or other stresses that appear to increase cellular thermal tolerance and enable cells to recover from stress. Some heat shock proteins may protect other proteins from denaturation, degradation or perform functions essential to cell survival under these conditions. [ ]

Term info

Label

Heat Shock Protein

Synonyms
  • HSP
  • Heat Shock Protein
  • Heat Shock Proteins
  • heat-shock protein
  • stress protein
ALT DEFINITION

One of a group of proteins that help protect cells from stresses such as heat, cold, and low amounts of oxygen or glucose (sugar). Heat-shock proteins help other proteins function in normal cells and may be present at high levels in cancer cells. Blocking the activity of a heat-shock protein called HSP90 is being studied in the treatment of cancer. Other heat-shock proteins including HSP70 and gp96 are being studied in vaccines to treat cancer.

Legacy Concept Name

Heat_Shock_Protein

Preferred Name

Heat Shock Protein

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0018850

code

C16672