Terminology Service for NFDI4Health
JSON

Histone Deacetylase

Go to external page http://purl.obolibrary.org/obo/NCIT_C16682

Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases. There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM) [ ]

Term info

Label

Histone Deacetylase

Synonyms
  • HDAC
  • Histone Deacetylase
  • histone deacetylase
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

ALT DEFINITION

An enzyme that removes a small molecule called an acetyl group from histones (proteins found in chromosomes). This changes the way the histones bind to DNA and may affect its activity. HDAC inhibitors are being studied in the treatment of cancer.

Display Name

Histone Deacetylase

Legacy Concept Name

Histone_Deacetylase

Preferred Name

Histone Deacetylase

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

UMLS CUI

C0019643

code

C16682