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Imatinib Mesylate

Go to external page http://purl.obolibrary.org/obo/NCIT_C1687

The mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST). [ ]

Term info

Label

Imatinib Mesylate

Synonyms
  • 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Monomethanesulfonate
  • CGP 57148
  • CGP57148B
  • Gleevec
  • Glivec
  • IMATINIB MESYLATE
  • Imatinib Mesylate
  • STI 571
  • STI-571
  • STI571
  • imatinib mesylate
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A drug used to treat different types of leukemia and other cancers of the blood, gastrointestinal stromal tumors, skin tumors called dermatofibrosarcoma protuberans, and a rare condition called systemic mastocytosis. It is also being studied in the treatment of other types of cancer. Imatinib mesylate blocks the protein made by the bcr/abl oncogene. It is a type of tyrosine kinase inhibitor.

Accepted Therapeutic Use For

Philadelphia chromosome-positive chronic myelogenous leukemia and acute lymphocytic leukemia, gastrointestinal stromal tumor, hypereosinophillic syndrome, dermatofibrosarcoma protuberans, mutated-PDGFR myelodysplastic/myeloproliferative diseases.

CAS Registry

220127-57-1

CHEBI ID

CHEBI:31690

Chemical Formula

C29H31N7O.CH4O3S

Display Name

Imatinib Mesylate

FDA UNII Code

8A1O1M485B

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C62035

Has Target

http://purl.obolibrary.org/obo/NCIT_C17322, http://purl.obolibrary.org/obo/NCIT_C17328, http://purl.obolibrary.org/obo/NCIT_C16325

NSC Code

716051

Preferred Name

Imatinib Mesylate

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0939537

code

C1687

Term relations

Related from:
Chemotherapy_Regimen_Has_Component