Terminology Service for NFDI4Health

Oncogene

Go to external page http://purl.obolibrary.org/obo/NCIT_C16936


A gene that normally directs cell growth. If mutated or overexpressed in a dominant fashion, it can release the cell from normal restraints on growth. It alone or in concert with other changes, converts the cell into a tumor cell. Alterations can be inherited or caused by an environmental exposure to carcinogens. [ ]

Term info

Label

Oncogene

Synonyms
  • Cancer-Promoting Gene
  • Oncogene
  • oncogene
ALT DEFINITION

A gene that is a mutated (changed) form of a gene involved in normal cell growth. Oncogenes may cause the growth of cancer cells. Mutations in genes that become oncogenes can be inherited or caused by being exposed to substances in the environment that cause cancer.

Gene Encodes Product

Oncoprotein

Preferred Name

Oncogene

Semantic Type

Gene or Genome

UMLS CUI

C0029016

code

C16936