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Plasminogen Activator Inhibitor 1

Go to external page http://purl.obolibrary.org/obo/NCIT_C16947

Plasminogen activator inhibitor 1 (402 aa, ~45 kDa) is encoded by the human SERPINE1 gene. This protein plays a role in both cell adhesion and the modulation of plasmin activity. [ ]

Term info

Label

Plasminogen Activator Inhibitor 1

Synonyms
  • Endothelial Plasminogen Activator Inhibitor
  • Nexin
  • PAI
  • PAI-1
  • PAI1
  • PLANH1
  • Plasminogen Activator Inhibitor 1
  • Plasminogen Activator Inhibitor Type 1
  • Plasminogen Activator Inhibitor-1
  • SERPINE1
  • Serine or Cysteine Proteinase Inhibitor Clade E Member 1
  • Serpin E1
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Plasminogen Activator Inhibitor-1 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. PAI1 shows structural similarities to angiotensinogen, alpha-1-antitrypsin, and antithrombin III and also regulates motility through the interaction of vitronectin with its receptor, integrin alpha-V-beta-3. (from OMIM 173360)

Display Name

Plasminogen Activator Inhibitor 1

Legacy Concept Name

Plasminogen_Activator_Inhibitor-1

OMIM Number

173360

Preferred Name

Plasminogen Activator Inhibitor 1

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

P05121

UMLS CUI

C0030190

code

C16947