Terminology Service for NFDI4Health
Plasminogen Activator Inhibitor 2
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http://purl.obolibrary.org/obo/NCIT_C16948
Plasminogen activator inhibitor 2 (415 aa, ~47 kDa) is encoded by the human SERPINB2 gene. This protein plays a role in the modulation of both plasmin activation and apoptosis. [ ]
Term info
Label
Plasminogen Activator Inhibitor 2
Synonyms
- Arginine-Serpin
- Monocyte Arg-Serpin
- PAI
- PAI-2
- PLANH2
- Placental Plasminogen Activator Inhibitor
- Plasminogen Activator Inhibitor 2
- Plasminogen Activator Inhibitor Type II
- Plasminogen Activator Inhibitor-2
- SERPINB2
- Serine or Cysteine Proteinase Inhibitor Clade B Member 2
- Serpin B2
- Urokinase Inhibitor
DesignNote
Plasminogen Activator Inhibitor-2 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. PAI2 (monocyte Arg-serpin) also belongs to the serine protease subfamily in which target specificity is determined by an Arg residue at its reactive center: Met/Val for elastase, Leu for kinase, and Arg for thrombin. PAI2 is thought to regulate plasminogen activation in extravascular compartments and high levels are found in keratinocytes, monocytes, and the trophoblast. (from OMIM 173390)
Legacy Concept Name
Plasminogen_Activator_Inhibitor-2
OMIM Number
173390
Preferred Name
Plasminogen Activator Inhibitor 2
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
P05120
UMLS CUI
C0030191
code
C16948