Terminology Service for NFDI4Health
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Protein Kinase C

Go to external page http://purl.obolibrary.org/obo/NCIT_C17017

A family of serine/threonine protein kinases that have a structurally conserved catalytic subunit and a regulatory subunit that are connected by a hinge domain. [ ]

Term info

Label

Protein Kinase C

Synonyms
  • EC 2.7.11.13
  • PKC
  • Protein Kinase C
  • protein kinase C
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

ALT DEFINITION

An enzyme found throughout the body's tissues and organs. Several forms of PKC are involved in many cellular functions. PKC is being studied in the treatment of cancer.

DesignNote

There are 3 classes of protein kinase C isozymes based on the molecular requirement for activation. Conventional isozymes need calcium ions, diacylglycerol and phospholipids for activation. Novel isozymes require diacylglycerol and are not regulated by calcium ions, while atypical isozymes require neither diacylglycerol nor calcium ions.

Display Name

Protein Kinase C

Legacy Concept Name

Protein_Kinase-C

Preferred Name

Protein Kinase C

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

UMLS CUI

C0033634

code

C17017