Terminology Service for NFDI4Health
Tipifarnib
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http://purl.obolibrary.org/obo/NCIT_C1703
A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04) [ ]
Term info
Label
Tipifarnib
Synonyms
- (+)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
- R115777
- TIPIFARNIB
- Tipifarnib
- Zarnestra
- tipifarnib
Subsets
NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C116977, NCIT_C157711, NCIT_C157712
ALT DEFINITION
A substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors.
CAS Registry
192185-72-1
Chemical Formula
C27H22Cl2N4O
Contributing Source
CTRP, FDA
Display Name
Tipifarnib
FDA UNII Code
MAT637500A
Has Target
http://purl.obolibrary.org/obo/NCIT_C17526
Legacy Concept Name
Tipifarnib
NSC Code
702818
PDQ Open Trial Search ID
42626
Preferred Name
Tipifarnib
Semantic Type
Pharmacologic Substance, Organic Chemical
UMLS CUI
C1176289
code
C1703
Term relations
Subclass of:
- Farnesyl Transferase Inhibitor
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Enzyme Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Inhibition of Cell Proliferation
- Chemical_Or_Drug_Has_Physiologic_Effect some Signal Transduction Inhibition
- Chemical_Or_Drug_Affects_Gene_Product some Farnesyl Protein Transferase
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Angiogenesis
- Chemical_Or_Drug_Has_Physiologic_Effect some Farnesylation Inhibition
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