Estrogen Receptor Family
Widely expressed human Estrogen Receptors (NR3 Family) are cytoplasmic hormone-activated receptors that act as nuclear transcription factors composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. Binding to DNA as a homo- or heterodimer, ESR interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR complexes appear to recognize discrete upstream target ERE DNA sequences to regulate gene expression, cell proliferation, and differentiation. DNA-binding is lost in the absence of ligand. (NCI) [ ]
Term info
Estrogen Receptor Family
- ER
- ER Family
- Estradiol Receptor
- Estrogen Receptor
- Estrogen Receptor Family
- Estrogen Receptor Family Protein
- NR3A
- Nuclear Receptor Subfamily 3 Group A
Estrogen_Receptor
Estrogen Receptor Family
Amino Acid, Peptide, or Protein, Receptor
C0034804
C17069
Term relations
- Steroid Hormone Receptor
- Gene_Product_Plays_Role_In_Biological_Process some Cell Proliferation
- Gene_Product_Plays_Role_In_Biological_Process some DNA Binding
- Gene_Product_Plays_Role_In_Biological_Process some Ligand Binding
- Gene_Product_Plays_Role_In_Biological_Process some Signal Transduction
- Gene_Product_Plays_Role_In_Biological_Process some Transcriptional Activation
- Gene_Product_Plays_Role_In_Biological_Process some Cell Differentiation Process
- Gene_Product_Is_Biomarker_Type some Tumor Marker
- Gene_Product_Is_Biomarker_Type some Cluster of Differentiation