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Tubulin

Go to external page http://purl.obolibrary.org/obo/NCIT_C17219

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink) [ ]

Term info

Label

Tubulin

Synonyms
  • Tubulin
  • tubulin
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

ALT DEFINITION

One of a group of proteins found in high levels in the cell cytoplasm (fluid inside a cell but outside the cell's nucleus). Tubulins are the building blocks of microtubules (narrow, hollow tubes inside a cell), which are involved in cell division and cell movement. Certain anticancer drugs bind to and block the formation or function of tubulins, which may block cell division.

Display Name

Tubulin

Preferred Name

Tubulin

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0041348

code

C17219