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Phosphatidylinositol-4,5-Bisphosphate 3-Kinase

Go to external page http://purl.obolibrary.org/obo/NCIT_C17270

An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, V(D)J recombination and cell cycle checkpoints. (from LocusLink) [ ]

Term info

Label

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase

Synonyms
  • 1-Phosphatidylinositol 3-Kinase
  • EC 2.7.1.153
  • PI 3 Kinase
  • PI3 Kinase
  • PI3 kinase
  • PI3-Kinase
  • PI3K
  • Phosphatidylinositide 3-Kinase
  • Phosphatidylinositol 3 Kinase
  • Phosphatidylinositol 3-Kinase
  • Phosphatidylinositol-3-Kinase
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase
  • Type I Phosphatidylinositol Kinase
  • Type III Phosphoinositide 3-Kinase
  • phosphatidylinositol-3 kinase
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

ALT DEFINITION

A type of enzyme that transmits signals in cells and that helps control cell growth. Some tumors have higher-than-normal levels of phosphatidylinositol-3 kinase.

Display Name

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase

Legacy Concept Name

Phosphatidylinositol-3_Kinase

Preferred Name

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

UMLS CUI

C0044602

code

C17270