Terminology Service for NFDI4Health

cAMP Responsive Element Binding Protein

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Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI) [ ]

Term info

Label

cAMP Responsive Element Binding Protein

Synonyms
  • CRE Binding Protein
  • CREB
  • CREB Protein
  • Cyclic AMP Responsive Element Binding Protein
  • cAMP Responsive Element Binding Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

cAMP Responsive Element Binding Protein

Legacy Concept Name

cAMP_Responsive_Element_Binding_Protein

Preferred Name

cAMP Responsive Element Binding Protein

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0056695

code

C17286