cAMP Responsive Element Binding Protein
Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI) [ ]
Term info
cAMP Responsive Element Binding Protein
- CRE Binding Protein
- CREB
- CREB Protein
- Cyclic AMP Responsive Element Binding Protein
- cAMP Responsive Element Binding Protein
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
cAMP Responsive Element Binding Protein
cAMP_Responsive_Element_Binding_Protein
cAMP Responsive Element Binding Protein
Amino Acid, Peptide, or Protein
C0056695
C17286
Term relations
- Transcription Factor
- Gene_Product_Plays_Role_In_Biological_Process some DNA Binding
- Gene_Product_Has_Structural_Domain_Or_Motif some Leucine Zipper
- Gene_Product_Has_Biochemical_Function some Signaling Protein
- Gene_Product_Has_Biochemical_Function some Sequence-Specific DNA Binding Protein
- Gene_Product_Encoded_By_Gene some CREB Family Gene