Terminology Service for NFDI4Health
Haptoglobin-Related Protein
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http://purl.obolibrary.org/obo/NCIT_C17299
Haptoglobin-related protein (348 aa, ~39 kDa) is encoded by the human HPR gene. This protein plays a role in hemoglobin binding. [ ]
Term info
Label
Haptoglobin-Related Protein
Synonyms
- HPR
- Haptoglobin-Related Protein
DesignNote
Haptoglobin-related protein (trypanosome lytic factor) confers human resistance to Trypanosome brucei. HPR or HPR-like epitopes are expressed in human breast carcinoma. Expression of HPR epitopes was associated with earlier recurrence, and multivariate analysis showed that HPR-epitope expression was an independent prognostic factor., Although homologous to serine proteases, haptoglobin-related protein is missing all of the essential catalytic residues; therefore, it has no enzymatic activity. (UniProt)
Legacy Concept Name
Haptoglobin-Related_Protein
OMIM Number
140210
Preferred Name
Haptoglobin-Related Protein
Semantic Type
Amino Acid, Peptide, or Protein, Immunologic Factor
Swiss Prot
P00739
UMLS CUI
C0062120
code
C17299
Term relations
Subclass of:
- Ligand Binding Protein
- Gene_Product_Malfunction_Associated_With_Disease some Hepatocellular Adenoma
- Gene_Product_Has_Associated_Anatomy some Serum
- Gene_Product_Encoded_By_Gene some HPR Gene
- Gene_Product_Is_Biomarker_Type some Prognostic Marker
- Gene_Product_Is_Biomarker_Of some Breast Carcinoma
- Gene_Product_Has_Structural_Domain_Or_Motif some Sushi Domain