Terminology Service for NFDI4Health
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Tumor Suppressor Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C17362

Tumor Suppressor Genes encode proteins whose functions inhibit expression of tumorigenic phenotypes by holding cellular proliferation in check. When inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (NCI) [ ]

Term info

Label

Tumor Suppressor Gene

Synonyms
  • Anti-Oncogene
  • Antioncogene
  • Tumor Suppressor
  • Tumor Suppressor Gene
  • Tumor Suppressors
  • antioncogene
  • tumor suppressor gene
ALT DEFINITION

A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA) in antioncogenes may lead to cancer.

Gene Encodes Product

Tumor Suppressor Protein

Legacy Concept Name

Tumor_Suppressor_Gene

Preferred Name

Tumor Suppressor Gene

Semantic Type

Gene or Genome

UMLS CUI

C0079427

code

C17362