Terminology Service for NFDI4Health

NF-kB

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NF-kB is a heterodimer complex of two DNA-binding subunits from two families of ubiquitous, inducible, nuclear transcription activators involved in cytokine-induced activation of gene expression. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-kB complex. NF-kB is inhibited by IkB proteins (NFKBIA or NFKBIB), which inactivate NF-kB by trapping it in the cytoplasm. Phosphorylation of IkB by kinases (IKBKA or IKBKB) marks them for ubiquitination, allowing NF-kB translocation to the nucleus and DNA binding at kappa-B transcription enhancer motifs. In B-lymphocytes, NF-kB binds to the immunoglobulin kappa light chain enhancer and in T-lymphocytes it binds to enhancers in virally infected cells, including HIV. (from OMIM 164011, 164012, 164910, 164014, 604758, and NCI) [ ]

Term info

Label

NF-kB

Synonyms
  • NF-Kappa B
  • NF-Kappa-B
  • NF-KappaB
  • NF-kB
  • NFKB
  • Nuclear Factor Kappa B
  • Nuclear Factor Kappa-B
  • Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
  • Nuclear Factor NF-Kappa-B
  • Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells
  • Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells
  • Nuclear Transcription Factor NF-kB
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

NF-kB

Semantic Type

Amino Acid, Peptide, or Protein, Immunologic Factor

UMLS CUI

C0079904

code

C17380