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Retinoic Acid Receptor

Go to external page http://purl.obolibrary.org/obo/NCIT_C17532

Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity. [ ]

Term info

Label

Retinoic Acid Receptor

Synonyms
  • Nuclear Receptor Subfamily 1 Group B
  • RAR
  • Retinoic Acid Receptor
  • Retinoid Receptor
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

A protein that binds retinoic acid with high affinity. Binding of ligand to RARs attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. (from OMIM 180240 and NCI)

Display Name

Retinoic Acid Receptor

Legacy Concept Name

Retinoic_Acid_Receptor

Preferred Name

Retinoic Acid Receptor

Semantic Type

Amino Acid, Peptide, or Protein, Receptor

UMLS CUI

C0140278

code

C17532