Terminology Service for NFDI4Health

Retinoid X Receptor

Go to external page http://purl.obolibrary.org/obo/NCIT_C17534


Human nuclear Retinoid X Receptors RXRA, RXRB, and RXRG (NR2/RXR Family) are transcriptional regulators composed of N-terminal modulating domain, DNA-binding domain (AGGTCA response elements), and C-terminal 9-cis RA-binding domain. RXR homodimers and RXR/RAR heterodimers mediate distinct retinoic acid response pathways. RXRs also interact with TH- and vitamin D receptors, and with NCOA3, NCOA6, PML, and PPARG coactivators; and mediate RA biological effects by binding to specific target gene promoters and inducing target gene transcription. RXRs/LXRs and RXRs/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI) [ ]

Term info

Label

Retinoid X Receptor

Synonyms
  • Nuclear Receptor Subfamily 2 Group B
  • RXR
  • Retinoic Acid Receptor RXR
  • Retinoid X Receptor
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

Retinoid X Receptor

Legacy Concept Name

Retinoid-X_Receptor

Preferred Name

Retinoid X Receptor

Semantic Type

Amino Acid, Peptide, or Protein, Receptor

UMLS CUI

C0140283

code

C17534