Terminology Service for NFDI4Health
Tissue Inhibitor of Metalloproteinases
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http://purl.obolibrary.org/obo/NCIT_C17544
Tissue inhibitors of metalloproteinase. A family of proteins of around 200 residues that can inhibit enzymes of the metalloprotease type, for example collagenase, by binding to them. (DCB-CB) [ ]
Term info
Label
Tissue Inhibitor of Metalloproteinases
Synonyms
- TIMP
- Tissue Inhibitor of Metalloproteinases
DesignNote
TIMP family members may possess selective affinities for matrix metalloproteinases. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions.
Legacy Concept Name
Tissue_Inhibitor_of_Metalloproteinases
Preferred Name
Tissue Inhibitor of Metalloproteinases
Semantic Type
Amino Acid, Peptide, or Protein
UMLS CUI
C0145988
code
C17544
Term relations
Subclass of:
- Enzyme Inhibitor Protein
- Gene_Product_Plays_Role_In_Biological_Process some Regulation of Proteolysis
- Gene_Product_Plays_Role_In_Biological_Process some Protein Degradation Inhibition
- Gene_Product_Plays_Role_In_Biological_Process some Enzyme Inhibition
- Gene_Product_Encoded_By_Gene some Proteinase Inhibitor Gene