Terminology Service for NFDI4Health
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I Kappa B

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A family of proteins that bind to the nuclear localization signal (NLS) domains of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) transcription factor complexes. This sequesters NF-kappaB in the cytoplasm and prevents its binding to the activation domains of target genes in the nucleus. Phosphorylation of I kappa B proteins, which is catalyzed by cytokine-activated I kappa B kinases (IKBK; IKK), disrupts binding to NF-kappaB and induces the degradation of I kappa B; this allows NF-kappaB to enter the nucleus and activate the transcription of target genes. [ ]

Term info

Label

I Kappa B

Synonyms
  • I Kappa B
  • I-Kappa-B
  • IKB
  • IKappaB
  • IkappaB
  • Inhibitor of Kappa B
  • NF-Kappa B Inhibitor
  • NF-Kappa-B Inhibitor
  • NFKB Inhibitor
  • NFKBI
  • Nuclear Factor Kappa-B Inhibitor
  • Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

I kappa B proteins have an N-terminal regulatory domain, followed by six or more ankyrin repeats and a PEST domain near their C terminus.

Display Name

I Kappa B

Legacy Concept Name

I-Kappa-B_Protein

Preferred Name

I Kappa B

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0167954

code

C17583