Terminology Service for NFDI4Health
Core-Binding Factor
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http://purl.obolibrary.org/obo/NCIT_C17683
CBF is an alpha/beta heterodimeric transcription factor involved in the transcriptional regulation of several genes important in hematopoiesis. The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA. [ ]
Term info
Label
Core-Binding Factor
Synonyms
- CBF
- Core-Binding Factor
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
Display Name
Core-Binding Factor
Legacy Concept Name
Core-Binding_Factor
Preferred Name
Core-Binding Factor
Semantic Type
Amino Acid, Peptide, or Protein
UMLS CUI
C0212320
code
C17683