Terminology Service for NFDI4Health
Oxidative Stress
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http://purl.obolibrary.org/obo/NCIT_C17741
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products. The damage to biological tissues is caused by superoxide and other free radicals generated by many factors, including exposure to alcohol, medications, trauma, cold, toxins, and radiation or by antimicrobial cellular immunity, metabolic abnormality, or "normal" aging; not synonymous with hypoxia or hyperoxia. Oxidative stress promotes a range of degenerative disorders, including cancer, diabetes, premature aging, Alzheimer's, and many others. [ ]
Term info
Label
Oxidative Stress
Synonyms
- Oxidative Stress
- oxidative stress
ALT DEFINITION
A condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.
Legacy Concept Name
Oxidative_Stress
Preferred Name
Oxidative Stress
Semantic Type
Phenomenon or Process
UMLS CUI
C0242606
code
C17741