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Multidrug Resistance Process

Go to external page http://purl.obolibrary.org/obo/NCIT_C17745

Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins. [ ]

Term info

Label

Multidrug Resistance Process

Synonyms
  • MDR
  • MULTIPLE DRUG RESISTANCE
  • Multidrug Resistance Process
  • Multiple Drug Resistance
  • multidrug resistance
Subsets

NCIT_C66830, NCIT_C61410, NCIT_C102577

ALT DEFINITION

Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective., Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.

Legacy Concept Name

Multidrug_Resistance

Preferred Name

Multidrug Resistance Process

Semantic Type

Phenomenon or Process

UMLS CUI

C0242640

code

C17745