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Heat Shock Protein 90

Go to external page http://purl.obolibrary.org/obo/NCIT_C17766

A family of structurally related proteins that play a role in cell signalling, protein folding and cellular stress responses. The members of this family are approximately 90 kDa. [ ]

Term info

Label

Heat Shock Protein 90

Synonyms
  • HSP-90
  • HSP90
  • Heat Shock Protein 90
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The Heat Shock Protein 90 members HSP89-alpha and HSP89-beta are a class of cytoplasmic molecular chaperone homodimers that act in the signal transduction mechanism of steroid receptors and may have ATPase activity. CDC37 and HSP90 associate preferentially with CDK4 not bound to type D cyclins. HSPA8, HSP90A, CXCR4, and GDF5 on monocytes form an activation cluster after LPS ligation and are involved in LPS signal transduction. (OMIM 140571, Swiss-Prot P07900, P08238)

Display Name

Heat Shock Protein 90

Legacy Concept Name

Heat_Shock_Protein-90

Preferred Name

Heat Shock Protein 90

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0243044

code

C17766