Terminology Service for NFDI4Health
BCL2 Gene
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http://purl.obolibrary.org/obo/NCIT_C17963
This gene is involved in apoptotic regulation. Overexpression of this gene promotes the pathogenesis of B-Cell lymphomas, due to anti-apoptotic activity. [ ]
Term info
Label
BCL2 Gene
Synonyms
- B-Cell CLL/Lymphoma 2 Gene
- BCL2
- BCL2 Gene
- BCL2, Apoptosis Regulator Gene
Subsets
NCIT_C116977, NCIT_C142801, NCIT_C142800, NCIT_C142799
ALT DEFINITION
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying.
Contributing Source
CTRP
Display Name
BCL2 Gene
HGNC ID
HGNC:990
Legacy Concept Name
BCL2_Gene
Maps To
BCL2
OMIM Number
151430
Preferred Name
BCL2 Gene
Semantic Type
Gene or Genome
UMLS CUI
C0376515
code
C17963
Term relations
Subclass of:
- BCL-2 Gene Family
- Gene_Involved_In_Pathogenesis_Of_Disease some Grade 3 Follicular Lymphoma
- Gene_Involved_In_Pathogenesis_Of_Disease some Grade 2 Follicular Lymphoma
- Gene_Plays_Role_In_Process some B-Cell Activation
- Gene_Has_Abnormality some Clonal BCL2 Gene Rearrangement
- Gene_Plays_Role_In_Process some Negative Regulation of Apoptosis
- Gene_Involved_In_Pathogenesis_Of_Disease some Ann Arbor Stage I Follicular Lymphoma
- Gene_Has_Abnormality some BCL2 Gene mRNA Overexpression
- Gene_Involved_In_Pathogenesis_Of_Disease some Grade 1 Follicular Lymphoma
- Gene_Has_Abnormality some BCL2 Gene Translocation
- Gene_Involved_In_Pathogenesis_Of_Disease some Ann Arbor Stage II Follicular Lymphoma
- Gene_Involved_In_Pathogenesis_Of_Disease some Ann Arbor Stage IV Follicular Lymphoma
- Gene_Involved_In_Pathogenesis_Of_Disease some EZB Diffuse Large B-Cell Lymphoma
- Gene_Involved_In_Pathogenesis_Of_Disease some Ann Arbor Stage III Follicular Lymphoma