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ZBTB16/RARA Fusion Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C18292

A fusion protein encoded by the ZBTB16/RARA fusion gene. This protein is comprised of the N-terminal POZ domain and two of the nine zinc fingers of zinc finger and BTB domain-containing protein 16 fused to the C-terminal DNA and ligand binding domains of the retinoic acid receptor alpha protein. [ ]

Term info

Label

ZBTB16/RARA Fusion Protein

Synonyms
  • PLZF-RAR-alpha Fusion Protein
  • PLZF-RARA Chimera
  • PLZF-RARalpha
  • PLZF-RARalpha Fusion Protein
  • PLZF/RARa Protein
  • Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha Chimera
  • ZBTB16-RARA Fusion Protein
  • ZBTB16/RARA Fusion Protein
  • ZNF145/RARA Chimera
  • Zinc Finger and BTB Domain-Containing Protein 16/Retinoic Acid Receptor Alpha Fusion Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Due to alternative splicing of the ZBTB16 gene, two forms of the ZBTB16/RARA fusion protein can be detected: ZBTB16-RARA Isoform A (735 amino acids, ~81 kDa) is composed of the N-terminal part of zinc finger and BTB domain-containing protein 16 including POZ domain and two of the nine zinc fingers, fused to the DNA and ligand binding domains of the retinoic acid receptor alpha protein; ZBTB16-RARA Isoform B (858 amino acids, ~93 kDa) differs from Isoform A by the inclusion of a 123 amino acid proline-rich region from zinc finger and BTB domain-containing protein 16. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)

Display Name

ZBTB16/RARA Fusion Protein

Legacy Concept Name

PLZF-RARalpha

Preferred Name

ZBTB16/RARA Fusion Protein

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C28635, http://purl.obolibrary.org/obo/NCIT_C21571

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0765587

code

C18292