ETS Family Gene
The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. The family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. To direct signals to specific target genes, ETS proteins interact with other transcription factors that determine the binding specificity of ETS proteins to RAS-response elements in target genes. [ ]
Term info
ETS Family Gene
- ETS Family Gene
- ETS Family Proto-Oncogenes
ETS Family Protein
ETS_Family_Gene
ETS Family Gene
Gene or Genome
C0812200
C18326
Term relations
- Transcription Factor Gene
- Gene_Plays_Role_In_Process some Transcriptional Regulation
- Gene_Found_In_Organism some Human