Terminology Service for NFDI4Health
Soluble Epidermal Growth Factor Receptor
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http://purl.obolibrary.org/obo/NCIT_C18436
Soluble epidermal growth factor receptor is encoded by the human EGFR gene. This protein may be involved in the regulation of epidermal growth factor receptor signaling. There are 3 described isoforms; all soluble forms lack the transmembrane and intracellular domain of the epidermal growth factor receptor. [ ]
Term info
Label
Soluble Epidermal Growth Factor Receptor
Synonyms
- EGFR
- EGFR ECD
- EGFR Extracellular Domain
- EGFR-ECD
- Epidermal Growth Factor Receptor Extracellular Domain
- Epidermal Growth Factor Receptor, Soluble
- Soluble Epidermal Growth Factor Receptor
- Soluble ErbB-1
- sEGFR
- sErbB-1
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
A secreted form of erbB1 that may have utility as a tumor marker., Soluble epidermal growth factor receptor does not have tyrosine kinase activity.
Display Name
Soluble Epidermal Growth Factor Receptor
Legacy Concept Name
Soluble_ERBB-1_Protein
Preferred Name
Soluble Epidermal Growth Factor Receptor
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
P00533
UMLS CUI
C1368111
code
C18436
Term relations
Subclass of:
- EGFR Gene Product
- Gene_Product_Plays_Role_In_Biological_Process some Cell Proliferation
- Gene_Product_Plays_Role_In_Biological_Process some Cell-Cell Adhesion Process
- Gene_Product_Plays_Role_In_Biological_Process some Signal Transduction
- Gene_Product_Encoded_By_Gene some EGFR Gene
- Gene_Product_Is_Biomarker_Type some Tumor Marker
- Gene_Product_Plays_Role_In_Biological_Process some Cellular Migration Process