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Suramin Sodium

Go to external page http://purl.obolibrary.org/obo/NCIT_C1848

A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. [ ]

Term info

Label

Suramin Sodium

Synonyms
  • 309 F
  • 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt
  • Antrypol
  • Bayer 205
  • Belganyl
  • CI-1003
  • Fourneau 309
  • Germanin
  • Metaret
  • Moranyl
  • Naganin
  • Naganinum
  • Naganol
  • Naphuride
  • SURAMIN SODIUM
  • Sodium Suramin
  • Sodium suramin
  • Suramin Hexasodium
  • Suramin Sodium
  • Suramin sodium
Subsets

NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C157712

Accepted Therapeutic Use For

African trypanosomiasis; onchocerciasis

CAS Registry

129-46-4

Chemical Formula

C51H34N6O23S6.6Na

FDA UNII Code

89521262IH

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C853

Has Target

http://purl.obolibrary.org/obo/NCIT_C17322, http://purl.obolibrary.org/obo/NCIT_C17068, http://purl.obolibrary.org/obo/NCIT_C41029, http://purl.obolibrary.org/obo/NCIT_C17293

Legacy Concept Name

Suramin_Sodium

NSC Code

34936

Preferred Name

Suramin Sodium

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0813205

code

C1848