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TPM3/NTRK1 Fusion Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C18548

A fusion protein (641 aa, ~72 kDa) encoded by the TPM3/NTRK1 fusion gene. This protein is comprised of most of the tropomyosin alpha-3 chain protein fused to the C-terminus of the high affinity nerve growth factor receptor protein, including an intact tyrosine kinase domain. [ ]

Term info

Label

TPM3/NTRK1 Fusion Protein

Synonyms
  • NTRK1/Tropomyosin Chimeric Protein
  • TPM3-NTRK1 Fusion Protein
  • TPM3/NTRK1 Fusion Protein
  • Tropomyosin Alpha-3 Chain/ High Affinity Nerve Growth Factor Receptor Fusion Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The TPM3/NTRK1 fusion protein is a constitutively activated tyrosine kinase.

Display Name

TPM3/NTRK1 Fusion Protein

Legacy Concept Name

NTRK1_Tropomyosin_Chimeric_Protein

Preferred Name

TPM3/NTRK1 Fusion Protein

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C97849, http://purl.obolibrary.org/obo/NCIT_C18551

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0919484

code

C18548